Description

4'-Bromo-2'-Fluorobiphenyl-4-Sulfonyl Chloride is a high-purity, multi-functional organic intermediate of significant importance in advanced chemical synthesis. Its core value lies in its reactive sulfonyl chloride group and halogenated biphenyl scaffold, making it a versatile building block for constructing complex molecular architectures. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the synthesis of monomers for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized to create sulfonamide-based probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis and Contract Manufacturing: A critical raw material for fine chemical companies offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	4'-Bromo-2'-Fluorobiphenyl-4-Sulfonyl Chloride
CAS No.	677326-82-8
Molecular Formula	C12H7BrClFO2S
Molecular Weight	349.60 g/mol
Synonyms	4-Bromo-2-fluorobiphenyl-4'-sulfonyl chloride; 2-Fluoro-4'-bromobiphenyl-4-sulfonyl chloride; [1,1'-Biphenyl]-4-sulfonyl chloride, 4'-bromo-2'-fluoro-; 4'-Bromo-2'-fluorobiphenyl-4-sulfonyl chloride; 2'-Fluoro-4'-bromobiphenyl-4-sulfonyl chloride; 4-(4-Bromo-2-fluorophenyl)benzenesulfonyl chloride; Biphenyl-4-sulfonyl chloride, 4'-bromo-2'-fluoro- derivative
EINECS	Contact for details

Quality Control

Our 4'-Bromo-2'-Fluorobiphenyl-4-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality parameters. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.