Description

4-[4-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Phenoxy]-Benzenesulfonyl Chloride is a high-purity, reactive chemical intermediate designed for advanced synthesis. This compound matters for its role as a key building block in the creation of complex molecules, offering a unique combination of a sulfonyl chloride group and a maleimide moiety for selective conjugation. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing novel active ingredients, polymers, and bioconjugates where precise and stable linkage is critical.

Application

• Pharmaceutical Intermediates: A critical building block for the synthesis of targeted therapeutics, including antibody-drug conjugates (ADCs) and small molecule inhibitors.
• Bioconjugation Reagent: Used to create stable covalent bonds between proteins, peptides, or antibodies and other molecules (e.g., drugs, dyes, polymers) via its maleimide and sulfonyl chloride functionalities.
• Polymer & Material Science: Serves as a cross-linking agent or functional monomer in the production of specialty polymers, hydrogels, and smart materials with tailored properties.
• Agrochemical Synthesis: Employed in the research and development of novel crop protection agents and pesticides.
• Diagnostic Reagents: Utilized in the manufacture of diagnostic assay components, such as enzyme labels and fluorescent probes.
• Surface Modification: Facilitates the functionalization of surfaces (e.g., glass, gold, polymers) for biosensor and microarray applications.

Basic Information

Item	Details
Product Name	4-[4-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Phenoxy]-Benzenesulfonyl Chloride
CAS No.	677326-81-7
Molecular Formula	C16H10ClNO5S
Molecular Weight	363.77 g/mol
Synonyms	1-[4-(4-Chlorosulfonylphenoxy)phenyl]-1H-pyrrole-2,5-dione; 4-(4-Maleimidophenoxy)benzenesulfonyl chloride; N-[4-(4-Chlorosulfonylphenoxy)phenyl]maleimide; Maleimide-PEG4-Sulfonyl Chloride (related); Sulfonyl chloride maleimide crosslinker; 4-Maleimidophenyl sulfone chloride; Reactive maleimide linker
EINECS	Contact for details

Quality Control

Our 4-[4-(2,5-Dioxo-2,5-Dihydro-Pyrrol-1-Yl)-Phenoxy]-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance for sensitive applications like bioconjugation and pharmaceutical synthesis. Certificates of Analysis (COA) with full specification data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.