Description

1-Azakenpaullone is a potent and selective cell-permeable inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3). This compound matters as a critical research tool for studying cell cycle regulation, signal transduction pathways, and neurodegenerative disease models. Researchers in pharmaceutical R&D, academic biochemistry, and neurobiology laboratories need it for high-precision mechanistic studies and drug discovery screening.

Application

• Biochemical Research: Used as a selective ATP-competitive inhibitor to study the roles of CDKs (e.g., CDK1, CDK2, CDK5) and GSK-3β in cellular processes.
• Neurodegenerative Disease Modeling: Employed in research on Alzheimer's disease, tauopathies, and other neurological disorders due to its inhibition of GSK-3, a key kinase involved in tau protein phosphorylation.
• Cell Cycle & Oncology Studies: A valuable tool for investigating cell cycle arrest, apoptosis, and proliferation in cancer cell lines.
• Signal Transduction Pathway Analysis: Helps elucidate the Wnt/β-catenin and other kinase-dependent signaling cascades.
• Drug Discovery & High-Throughput Screening (HTS): Serves as a reference compound or positive control in assays designed to identify novel kinase inhibitors.
• Stem Cell Research: Applied in studies focusing on the regulation of stem cell differentiation and self-renewal.

Basic Information

Product Name	1-Azakenpaullone
CAS No.	676596-65-9
Molecular Formula	C13H9N3O2
Molecular Weight	239.23 g/mol
Synonyms	1-Azakenpaullone; 9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one; Kenpaullone analog; CDK Inhibitor; GSK-3 Inhibitor XV; ALX-270-460
EINECS	Contact for details

Quality Control

Our 1-Azakenpaullone is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive (store away from light). For long-term storage, consider keeping the container under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.