Description

3-Pyridinecarboxylic Acid, 6-Fluoro-, 1,1-Dimethylethyl Ester is a high-value fluorinated pyridine derivative, serving as a critical protected intermediate in advanced organic synthesis. Its core value lies in enabling the precise introduction of the 6-fluoro-3-pyridinecarboxylate moiety, a key structural motif sought after for its ability to modulate the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to construct novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and insecticides, where the fluorine atom enhances metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials that incorporate pyridine-based units.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring regioselectively fluorinated nicotinate derivatives.
• Academic & R&D Laboratories: Used in methodological studies and for exploring new synthetic routes involving fluorinated heterocycles.

Basic Information

Product Name	3-Pyridinecarboxylic Acid, 6-Fluoro-, 1,1-Dimethylethyl Ester
CAS No.	676560-01-3
Molecular Formula	C11H14FNO2
Molecular Weight	211.23 g/mol
Synonyms	tert-Butyl 6-fluoronicotinate; 6-Fluoronicotinic Acid tert-Butyl Ester; 1,1-Dimethylethyl 6-fluoro-3-pyridinecarboxylate; 6-Fluoro-3-pyridinecarboxylic acid tert-butyl ester; tert-Butyl 6-fluoro-3-pyridinecarboxylate; 6-Fluoropyridine-3-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-Pyridinecarboxylic Acid, 6-Fluoro-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Due to its chemical nature, it should be stored separately from strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.