Description

2'-Trifluoromethyl-Biphenyl-2-Carbaldehyde is a high-purity, specialized aromatic aldehyde building block featuring a biphenyl core substituted with a trifluoromethyl and a formyl group. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where the trifluoromethyl group is known to enhance metabolic stability and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides, leveraging the bioactivity of the trifluoromethyl-biphenyl moiety.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials and liquid crystals due to its rigid, fluorinated aromatic structure.
• Custom Synthesis and Contract Manufacturing: A vital building block for custom chemical synthesis services catering to drug discovery programs.

Basic Information

Product Name	2'-Trifluoromethyl-Biphenyl-2-Carbaldehyde
CAS No.	676348-34-8
Molecular Formula	C14H9F3O
Molecular Weight	250.22 g/mol
Synonyms	2'-(Trifluoromethyl)[1,1'-biphenyl]-2-carboxaldehyde; [1,1'-Biphenyl]-2-carboxaldehyde, 2'-(trifluoromethyl)-; 2-Formyl-2'-(trifluoromethyl)biphenyl; 2'-Trifluoromethyl-2-biphenylcarboxaldehyde; 2-Biphenylcarboxaldehyde, 2'-trifluoromethyl-; (2'-Trifluoromethyl-biphenyl-2-yl)-methanal
EINECS	Contact for details

Quality Control

Every batch of 2'-Trifluoromethyl-Biphenyl-2-Carbaldehyde is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), identity (by IR and NMR), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable supply for critical development and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is easily oxidized and should be stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.