Description

2-Amino-3,6-difluoro-4-(trifluoromethyl)pyridine is a high-value, multi-fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both amino and trifluoromethyl substituents on a difluoropyridine core, makes it indispensable for introducing fluorine atoms into complex molecules, thereby modulating their physicochemical properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine atoms improve biological activity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials that benefit from fluorine's unique electronic characteristics.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry: An important reagent for introducing the trifluoromethyl and difluoropyridine motifs into target molecules via cross-coupling or nucleophilic substitution reactions.

Basic Information

Product Name	2-Amino-3,6-difluoro-4-(trifluoromethyl)pyridine
CAS No.	675602-89-8
Molecular Formula	C6H3F5N2
Molecular Weight	198.10 g/mol
Synonyms	2-Amino-3,6-difluoro-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-amino-3,6-difluoropyridine; 3,6-Difluoro-4-trifluoromethyl-pyridin-2-ylamine; 2-Pyridinamine, 3,6-difluoro-4-(trifluoromethyl)-; 675602-89-8
EINECS	Contact for details

Quality Control

Our production of 2-Amino-3,6-difluoro-4-(trifluoromethyl)pyridine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.