Description

Furin Inhibitor Ii CAS NO 673202-67-0 is a potent and selective small molecule inhibitor of the proprotein convertase furin, a key enzyme involved in the proteolytic activation of various precursor proteins. This compound is a critical research tool for studying viral pathogenesis, cancer progression, and other biological processes dependent on furin-mediated cleavage. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic research sectors for target validation and therapeutic discovery.

Application

• Biomedical Research: Fundamental tool for investigating the role of furin in cellular signaling pathways, protein maturation, and disease mechanisms.
• Virology Studies: Used to inhibit the cleavage of viral envelope glycoproteins (e.g., SARS-CoV-2 Spike protein, HIV gp160, influenza hemagglutinin), blocking viral entry and infectivity in vitro.
• Oncology Research: Applied in studies targeting furin-dependent activation of growth factors (e.g., TGF-β, PDGF) and matrix metalloproteinases involved in tumor growth, invasion, and metastasis.
• Bacterial Toxin Research: Employed to study the activation of bacterial toxins such as Pseudomonas exotoxin A and anthrax protective antigen.
• Drug Discovery & Development: Serves as a reference compound and pharmacological probe in high-throughput screening and the development of novel furin-targeted therapeutics.
• Cell Biology: Used to modulate processing of hormones, neuropeptides, and receptors in cell culture models to elucidate their functions.

Basic Information

Product Name	Furin Inhibitor Ii
CAS No.	673202-67-0
Molecular Formula	C₂₉H₄₀N₄O₅
Molecular Weight	524.66 g/mol
Synonyms	Furin Inhibitor II; Decanoyl-RVKR-CMK; RVKR-CMK; CMK Inhibitor; Furin Inhibitor (RVKR-CMK); Chloromethylketone furin inhibitor; (2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-5-Amino-2-[[(2S)-1-[(2S)-5-amino-1-chloro-2-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methylpentanamido]-3-(4-hydroxyphenyl)propanamido]-4-methylpentanamido]-5-(diaminomethylideneamino)-1-chloropentan-2-one
EINECS	Contact for details

Quality Control

Our Furin Inhibitor Ii is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, mass spectrometry (MS) for identity confirmation, and NMR spectroscopy. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.