Description

(2'Z,3'E)-6-Bromoindirubin-3'-Acetoxime CAS NO 667463-85-6 is a chemically modified indirubin derivative, a class of compounds known for their potent biological activity. This specific brominated acetoxime analog is a critical research-grade intermediate and reference standard for investigating cellular signaling pathways. It is primarily utilized by pharmaceutical R&D, biotechnology, and academic research institutions focused on oncology, neurology, and metabolic disease studies. The compound's precise structure makes it valuable for high-throughput screening and mechanistic studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and intermediate in the synthesis of novel therapeutic agents targeting specific kinases and signaling pathways.
• Biochemical Assay Development: Used as a potent, selective inhibitor in enzymatic and cellular assays to study protein function and validate drug targets.
• Academic & Preclinical Studies: Employed in university and institutional labs for fundamental research into cell cycle regulation, apoptosis, and differentiation processes.
• High-Throughput Screening (HTS): Acts as a control compound or a lead structure in HTS campaigns to identify new drug candidates from chemical libraries.
• Chemical Biology Tool Compound: Utilized to probe biological systems and understand the role of specific molecular interactions in disease models.
• Standards for Analytical Testing: Provides a certified reference material for method development and quality control in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	(2'Z,3'E)-6-Bromoindirubin-3'-Acetoxime
CAS No.	667463-85-6
Molecular Formula	C19H14BrN3O3
Molecular Weight	412.24 g/mol
Synonyms	6-Bromoindirubin-3'-acetoxime; (Z,E)-6-Bromoindirubin-3'-acetoxime; 6-Br-indirubin-3'-oxime acetate; 6-Bromo-1H,1'H-[2,3'-biindole]-2',3(2H)-dione 3'-(O-acetyloxime); 6-Bromoindirubin 3'-(O-acetyloxime); Indirubin derivative 6-Br-3'-acetoxime; 6-Br-I3A; BR-I3A
EINECS	Contact for details

Quality Control

Our (2'Z,3'E)-6-Bromoindirubin-3'-Acetoxime is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This compound is light-sensitive (store away from light). For long-term storage, consider storing under inert atmosphere at -20°C.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Purity (Titration)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.