Description

Reversine (CAS NO 656820-32-5) is a potent and selective small molecule inhibitor of Aurora kinases and certain non-receptor tyrosine kinases, widely recognized for its role in cellular reprogramming and dedifferentiation research. This compound is a critical tool for investigating cell fate plasticity, cancer biology, and regenerative medicine pathways. It is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on kinase signaling, stem cell research, and oncology drug discovery.

Application

• Cellular Reprogramming & Dedifferentiation: Used to induce pluripotency or alter cell fate in various somatic cell types for regenerative medicine studies.
• Kinase Signaling Research: Serves as a selective chemical probe to study the biological functions of Aurora A/B kinases and non-receptor tyrosine kinases like JAK3.
• Cancer Biology & Oncology Research: Investigated for its effects on cell cycle arrest, apoptosis, and the reversal of malignant phenotypes in various cancer cell lines.
• Stem Cell Research: Facilitates the generation of multipotent progenitor cells from differentiated tissues for disease modeling and tissue engineering.
• Drug Discovery & Development: A valuable reference compound and starting point for developing novel therapeutics targeting kinase pathways in oncology and beyond.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro enzymatic assays to identify and characterize kinase inhibitors.

Basic Information

Product Name	Reversine
CAS No.	656820-32-5
Molecular Formula	C21H23N7O2
Molecular Weight	405.46 g/mol
Synonyms	2-(4-Morpholinoanilino)-6-cyclohexylaminopurine; 6-(Cyclohexylamino)-2-[(4-morpholinophenyl)amino]-9H-purine; N6-Cyclohexyl-2-((4-morpholinophenyl)amino)-9H-purin-6-amine; Aurora Kinase Inhibitor II; JAK3 Inhibitor VI; Dedifferentiation Inducer
EINECS	Contact for details

Quality Control

Our Reversine is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.