Description

n-Azidoacetylgalactosamine-Tetraacylated (Ac4Gainaz) is a chemically modified monosaccharide derivative, specifically a peracetylated GalNAc analog bearing an azido functional group. This compound matters as a critical metabolic chemical reporter and bioorthogonal handle for the selective labeling and study of glycoproteins and glycolipids in living systems. Researchers in chemical biology, glycoproteomics, and drug discovery need it for applications such as metabolic oligosaccharide engineering, cell surface glycan imaging, and the development of targeted therapeutics.

Application

• Metabolic Oligosaccharide Engineering (MOE): Serves as a precursor for the metabolic incorporation of azide-tagged GalNAc residues into cellular glycoconjugates.
• Bioorthogonal Labeling: The azido group enables highly selective conjugation via click chemistry (e.g., CuAAC, SPAAC) with alkyne-bearing probes for fluorescence imaging, affinity purification, or mass spectrometry.
• Glycoproteomics Research: Used to tag and enrich O-GalNAc (mucin-type) glycosylated proteins for identification and functional analysis.
• Cell Surface Engineering: Facilitates the installation of chemical functionalities onto cell membranes for studying cell-cell interactions, adhesion, and signaling.
• Antibody-Drug Conjugate (ADC) Development: Provides a chemoselective handle for the site-specific conjugation of cytotoxic payloads to antibodies or other targeting proteins.
• Vaccine and Immunotherapy Research: Employed in the synthesis of neoglycoconjugates for investigating immune responses and developing carbohydrate-based vaccines.

Basic Information

Product Name	n-Azidoacetylgalactosamine-Tetraacylated (Ac4Gainaz)
CAS No.	653600-56-7
Molecular Formula	C16H22N4O10
Molecular Weight	430.37 g/mol
Synonyms	Ac4GalNAz; 2-Azidoacetamido-2-deoxy-1,3,4,6-tetra-O-acetyl-α-D-galactopyranose; 1,3,4,6-Tetra-O-acetyl-2-azidoacetamido-2-deoxy-α-D-galactopyranose; N-Azidoacetyl-1,3,4,6-tetra-O-acetyl-α-D-galactosamine; Peracetylated N-azidoacetylgalactosamine; Tetra-O-acetyl-N-azidoacetyl-α-D-galactosamine; Ac4GalNAz; Metabolic GalNAz precursor
EINECS	Contact for details

Quality Control

Our n-Azidoacetylgalactosamine-Tetraacylated is produced under strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive biological research. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.