Description

Bay 61-3606 (Dihydrochloride) is a potent and selective small molecule inhibitor of the spleen tyrosine kinase (Syk). This compound is a critical research tool for investigating intracellular signaling pathways, particularly those involved in immune cell activation and function. It is essential for researchers in pharmaceutical development and life sciences studying inflammation, autoimmune disorders, and oncology. The product is supplied as the dihydrochloride salt, CAS NO 648903-57-5, to ensure optimal stability and handling.

Application

• Biochemical Research: Used as a selective Syk kinase inhibitor to study Fc receptor and B-cell receptor signaling pathways in immunology.
• Pharmaceutical R&D: Serves as a reference standard and key intermediate in the discovery and development of novel anti-inflammatory and autoimmune disease therapeutics.
• Cell Biology Studies: Employed to modulate immune cell responses (e.g., mast cells, B cells, macrophages) in in vitro and in vivo experimental models.
• Target Validation: A crucial tool for validating Syk as a therapeutic target in various disease contexts, including rheumatoid arthritis and lymphoma.
• High-Throughput Screening (HTS): Utilized as a control compound in assay development and screening campaigns for identifying new kinase inhibitors.

Basic Information

Product Name	Bay 61-3606 (Dihydrochloride)
CAS No.	648903-57-5
Molecular Formula	C₂₀H₂₂Cl₂N₈O₂
Molecular Weight	477.34 g/mol
Synonyms	Bay 61-3606; Bay 61-3606 2HCl; 6-({5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one dihydrochloride; Syk Inhibitor VI; 2,2-Dimethyl-6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-3-one dihydrochloride
EINECS	Contact for details

Quality Control

Our Bay 61-3606 (Dihydrochloride) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with every shipment to ensure reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. The product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.