Description

1-(Chloromethyl)-2-Fluoro-3-Methylbenzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both chloromethyl and fluorine substituents on a methylbenzene core, makes it a key intermediate for constructing complex molecules. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated organic electronic materials, contributing to improved performance in display technologies.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with tailored properties, such as enhanced chemical resistance or specific optical characteristics.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for creating biaryl structures common in many advanced materials.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D laboratories exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	1-(Chloromethyl)-2-Fluoro-3-Methylbenzene
CAS No.	647037-27-2
Molecular Formula	C8H8ClF
Molecular Weight	158.60 g/mol
Synonyms	2-Fluoro-3-methylbenzyl chloride; 3-Methyl-2-fluorobenzyl chloride; (2-Fluoro-3-methylphenyl)methyl chloride; 1-(Chloromethyl)-2-fluoro-3-methyl-benzene; α-Chloro-2-fluoro-3-methyltoluene; 2-Fluoro-α-chloro-3-methyltoluene; Benzene, 1-(chloromethyl)-2-fluoro-3-methyl-
EINECS	Contact for details

Quality Control

Our 1-(Chloromethyl)-2-Fluoro-3-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.