Description

2-Methyl-4-(Trifluoromethyl)Nicotinonitrile is a high-value, functionalized pyridine derivative characterized by its nitrile and trifluoromethyl substituents. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in modern synthetic chemistry. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, leveraging the biological activity imparted by the trifluoromethyl group.
• Ligand and Catalyst Development: Used in the synthesis of specialized ligands for transition metal catalysis and organocatalysts due to its electron-deficient pyridine core.
• Material Science Research: Building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring a specific, high-purity fluorinated heterocyclic nitrile.

Basic Information

Product Name	2-Methyl-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	643015-36-5
Molecular Formula	C8H5F3N2
Molecular Weight	186.14 g/mol
Synonyms	4-(Trifluoromethyl)-2-methylnicotinonitrile; 2-Methyl-4-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-2-methyl-4-(trifluoromethyl)pyridine; 2-Methyl-4-trifluoromethyl-3-cyanopyridine; 2-Methyl-4-(trifluoromethyl)-3-pyridinecarbonitrile; Nicotinonitrile, 2-methyl-4-(trifluoromethyl)-; 3-Pyridinecarbonitrile, 2-methyl-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Methyl-4-(Trifluoromethyl)Nicotinonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.