Description

Z-Vad(Oh)-Fmk is a potent, irreversible pan-caspase inhibitor widely used in biochemical and pharmaceutical research. This compound is critical for investigating apoptotic pathways and developing therapeutic strategies for diseases involving dysregulated cell death. It is an essential research tool for scientists in pharmaceutical R&D, academic biochemistry, and biotechnology.

Application

• Apoptosis Research: Fundamental tool for studying caspase-dependent cell death pathways in various cell types.
• Drug Discovery Screening: Used as a control or reference compound in high-throughput assays to identify novel anti-apoptotic or pro-apoptotic agents.
• Disease Mechanism Studies: Investigating the role of caspases in neurodegenerative diseases, ischemic injury, autoimmune disorders, and cancer.
• Cell Culture & Assay Development: Employed to prevent apoptosis in primary cell cultures or to validate the specificity of apoptosis detection assays.
• Biochemical Pathway Analysis: Used to inhibit caspase activity in protein lysates to study downstream signaling events.

Basic Information

Product Name	Z-Vad(Oh)-Fmk
CAS No.	634911-81-2
Molecular Formula	C22H31FN4O7
Molecular Weight	482.50 g/mol
Synonyms	Z-VAD-FMK; Z-VAD(OH)-FMK; Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone; Benzyloxycarbonyl-Val-Ala-Asp(OMe)-CH2F; Caspase Inhibitor Z-VAD-FMK; Z-Val-Ala-Asp(OMe)-FMK; Z-Val-Ala-Asp(OMe)-CH2F; Pan-Caspase Inhibitor
EINECS	Contact for details

Quality Control

Our Z-Vad(Oh)-Fmk is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, mass spectrometry (MS) confirmation, and NMR spectroscopy. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.