Description

Z-Asp(Ome)-Glu(Ome)-Val-Dl-Asp(Ome)-Fluoromethylketone is a specialized, high-purity peptide-based fluoromethyl ketone inhibitor. This compound is a critical research tool designed for the selective and irreversible inhibition of specific cysteine proteases, particularly caspases involved in apoptosis. It is essential for researchers and developers in the fields of biochemistry, cell biology, and pharmaceutical discovery. The product is supplied under stringent quality control to ensure batch-to-batch consistency for reliable experimental results.

Application

• Biochemical Research: Used as a potent, cell-permeable inhibitor to study caspase-mediated apoptotic pathways in cellular models.
• Pharmaceutical Development: Serves as a key reference standard and pharmacophore in the design and screening of novel anti-apoptotic drug candidates.
• Enzyme Mechanism Studies: Employed to elucidate the catalytic mechanism and substrate specificity of caspase-family proteases.
• Diagnostic Reagent Manufacturing: Incorporated into assay kits for the detection and quantification of caspase activity in research and clinical samples.
• Neuroscience Research: Applied in models of neurodegenerative diseases to investigate the role of apoptosis in neuronal cell death.
• Cancer Biology: Utilized to probe the resistance mechanisms of cancer cells to chemotherapeutic agents that induce apoptosis.

Basic Information

Product Name	Z-Asp(Ome)-Glu(Ome)-Val-Dl-Asp(Ome)-Fluoromethylketone
CAS No.	634911-78-7
Molecular Formula	C30H41FN4O12
Molecular Weight	644.67 g/mol
Synonyms	Z-DEVD-FMK; Caspase-3 Inhibitor II; Z-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-FMK; Ac-DEVD-CHO-FMK; Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone; Caspase 3/7 Inhibitor; Apoptosis Inhibitor Z-DEVD-FMK
EINECS	Contact for details

Quality Control

Every batch of Z-Asp(Ome)-Glu(Ome)-Val-Dl-Asp(Ome)-Fluoromethylketone is manufactured and analyzed under strict quality management protocols to ensure the highest standards of purity and biological activity. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with research-grade specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and assay results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (Assay)	Conforms to expected inhibitory potency

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.