Description

3-Fluoro-5-Trifluoromethylbenzyl Chloride is a versatile and highly functionalized benzyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of fluorine atoms and a reactive chloromethyl group, enabling precise molecular modifications to enhance the properties of target compounds. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require high-purity, reliable synthetic precursors.

Application

• Pharmaceutical Intermediate: Key precursor for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of molecules with improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl and fluorine groups contribute to enhanced activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce fluorinated benzyl groups into polymers, altering surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.
• Ligand & Catalyst Development: Useful for synthesizing specialized fluorinated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	3-Fluoro-5-Trifluoromethylbenzyl Chloride
CAS No.	634151-25-0
Molecular Formula	C8H5ClF4
Molecular Weight	212.57 g/mol
Synonyms	1-(Chloromethyl)-3-fluoro-5-(trifluoromethyl)benzene; (3-Fluoro-5-(trifluoromethyl)phenyl)methyl chloride; α-Chloro-3-fluoro-5-trifluoromethyltoluene; 3-Fluoro-α-chloro-α,α,α-trifluoro-p-xylene; 3-Fluoro-5-trifluoromethylbenzylchloride; 5-Trifluoromethyl-3-fluorobenzyl Chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-Trifluoromethylbenzyl Chloride is produced and tested under a strict quality management system. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure identity, purity, and consistency meet the exacting standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, containers should be kept sealed under an inert atmosphere such as nitrogen or argon when not in use. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.