Description

2,4-Dichloro-3-Fluoropyridine is a high-purity halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique substitution pattern, which provides distinct reactivity for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily needed by R&D chemists and process development scientists for applications in medicinal chemistry, crop protection, and material science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine substituents for bioactivity.
• Material Science Research: Used in the development of functionalized ligands for catalysis and in the creation of advanced organic electronic materials.
• Cross-Coupling Reactions: Serves as a versatile substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form biaryl systems.
• Nucleophilic Aromatic Substitution: The chlorine atoms at the 2 and 4 positions are amenable to selective displacement with various nucleophiles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up.

Basic Information

Product Name	2,4-Dichloro-3-Fluoropyridine
CAS No.	628691-85-0
Molecular Formula	C5H2Cl2FN
Molecular Weight	165.98 g/mol
Synonyms	3-Fluoro-2,4-dichloropyridine; 2,4-Dichloro-3-fluoropyridine; Pyridine, 2,4-dichloro-3-fluoro-; 3-Fluoro-2,4-dichloropyridine; 2,4-Dichloro-3-fluoro-pyridine; 628691-85-0 (CAS); 3-Fluoro-2,4-dichloro-pyridine
EINECS	Contact for details

Quality Control

Our 2,4-Dichloro-3-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee traceability and compliance with your project specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.