Description

4-Bromo-1-Chloro-2-Difluoromethylbenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), crop protection agents, and specialty materials who require reliable access to high-quality, well-characterized intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the difluoromethyl group for enhanced bioactivity and metabolic stability.
• Material Science: Serves as a monomer or functionalizing agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitution reactions to introduce complex functionalities into aromatic systems.
• Fluorine Chemistry: A valuable substrate for studying and applying fluorination techniques, contributing to the development of compounds with improved physicochemical properties.

Basic Information

Product Name	4-Bromo-1-Chloro-2-Difluoromethylbenzene
CAS No.	627527-07-5
Molecular Formula	C7H4BrClF2
Molecular Weight	241.46 g/mol
Synonyms	2-Bromo-5-Chlorobenzylidene Difluoride; 1-Bromo-4-Chloro-2-(difluoromethyl)benzene; 2-(Difluoromethyl)-5-chlorobromobenzene; 5-Chloro-2-(difluoromethyl)bromobenzene; Benzene, 1-bromo-4-chloro-2-(difluoromethyl)-; 4-Chloro-2-(difluoromethyl)bromobenzene; (4-Bromo-3-chlorophenyl)difluoromethane
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1-Chloro-2-Difluoromethylbenzene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards, and comprehensive analytical testing is performed using advanced techniques including GC, HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and meet your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥98.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.