Description

Nf449 CAS NO 627034-85-9 is a high-purity, small-molecule chemical compound widely recognized as a potent and selective inhibitor of soluble guanylyl cyclase (sGC). This compound matters for researchers and developers as it provides a critical tool for modulating the nitric oxide (NO)-sGC-cGMP signaling pathway, a key regulator in various physiological processes. It is primarily needed by the life sciences sector, including pharmaceutical R&D, academic biochemistry research, and biotechnology companies focused on cardiovascular, pulmonary, and neurological target validation.

Application

• Pharmacological Research: Used as a selective sGC inhibitor to study the role of the NO-sGC-cGMP pathway in cellular signaling and disease models.
• Cardiovascular Studies: Employed in investigating vascular tone, blood pressure regulation, and platelet aggregation mechanisms.
• Neurological Research: Applied in exploring the effects of cGMP signaling in neuroprotection, synaptic plasticity, and related disorders.
• Pulmonary Function Research: Utilized to examine airway relaxation and pulmonary hypertension pathways.
• Biochemical Assay Development: Serves as a reference standard or key component in high-throughput screening (HTS) and enzyme activity assays.
• Preclinical Drug Discovery: Acts as a chemical probe for target validation and for evaluating the efficacy of novel therapeutic candidates targeting the sGC pathway.

Basic Information

Product Name	Nf449
CAS No.	627034-85-9
Molecular Formula	C₂₈H₃₈N₁₀O₁₈P₄S₄
Molecular Weight	1010.88 g/mol
Synonyms	NF 449; 8,8'-[Carbonylbis(imino-4,1-phenylenecarbonylimino-4,1-phenylenecarbonylimino)]bis(1,3,5-naphthalenetrisulfonic acid) tetrasodium salt; sGC Inhibitor NF449; 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriylbis(carbonylimino)))tetrakis(benzene-1,3-disulfonic acid) tetrasodium salt; Guanylyl cyclase inhibitor NF449
EINECS	Contact for details

Quality Control

Our Nf449 is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines
Biological Activity (sGC Inhibition IC₅₀)	Reported value provided per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.