Description

Gsk-3β Inhibitor Xi is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 beta, a key enzyme involved in numerous cellular signaling pathways. This high-purity compound is essential for biochemical and pharmacological research, enabling the study of Wnt/β-catenin signaling, glucose metabolism, and neurodegenerative disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on drug discovery for conditions such as diabetes, Alzheimer's disease, and cancer.

Application

• Biochemical Research: Used as a critical tool compound to inhibit GSK-3β activity in in vitro enzyme assays and cell-based studies.
• Pharmaceutical R&D: Serves as a reference standard and lead compound in drug discovery programs targeting diabetes, mood disorders, and neurodegenerative diseases.
• Cell Signaling Studies: Facilitates the investigation of the Wnt signaling pathway, insulin response, and cellular proliferation mechanisms.
• Academic Research: Employed in university and institutional labs for fundamental research into tau protein phosphorylation, neuroinflammation, and stem cell differentiation.
• Target Validation: Used to confirm the biological role and therapeutic potential of GSK-3β in various disease models.

Basic Information

Product Name	Gsk-3β Inhibitor Xi
CAS No.	626604-39-5
Molecular Formula	C₁₆H₁₂N₄O₃
Molecular Weight	308.29 g/mol
Synonyms	6-Bromoindirubin-3'-oxime; BIO; (2'Z,3'E)-6-Bromoindirubin-3'-oxime; GSK-3 Inhibitor IX; 6-Bromoindirubin-3'-(Z)-oxime; 6-BIO; Axon 1683; GSK-3β Inhibitor XI
EINECS	Contact for details

Quality Control

Our Gsk-3β Inhibitor Xi is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.