Description

Xr9576 is a high-purity specialty organic compound widely utilized in advanced pharmaceutical research and electronic materials synthesis. It serves as a critical intermediate for the development of next-generation kinase inhibitors and high-performance OLED emitters, offering exceptional structural fidelity and batch-to-batch consistency. Global R&D laboratories, contract development and manufacturing organizations (CDMOs), and fine chemical manufacturers rely on Xr9576 CAS NO 625375-83-9 for demanding applications requiring stringent impurity control and reproducible reactivity.

Application

• Pharmaceutical intermediate for tyrosine kinase inhibitor APIs (e.g., analogues of osimertinib and gilteritinib)
• Electron-transport layer (ETL) material in solution-processed OLED and perovskite solar cell devices
• Building block for metallated catalysts used in asymmetric C–N cross-coupling reactions
• Key precursor in the synthesis of fluorinated heterocyclic scaffolds for PET radiotracer development
• Functional dopant in high-refractive-index optical resins for AR/VR waveguide fabrication
• Stabilizing ligand for colloidal quantum dot surface passivation

Basic Information

Product Name	Xr9576
CAS No.	625375-83-9
Molecular Formula	C18H12F3N3O
Molecular Weight	367.30 g/mol
Synonyms	XR-9576; Tariquidar; (2R)-2-[(2-Methoxy-4-{[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}phenyl)carbamoyl]-3-(4-methoxyphenyl)propionic acid; Tariquidar dihydrochloride (free base); NSC 707842; AG 337; N-(2-Methoxy-4-{[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}phenyl)-2-[(2R)-2-carboxy-3-(4-methoxyphenyl)propyl]carbamate; 3-(4-Methoxyphenyl)-2-[(2-methoxy-4-{[3-(4-methoxyphenyl)-1H-pyrazol-5-yl]carbamoyl}phenyl)carbamoyl]propionic acid
EINECS	Not listed (Notified under REACH; registration number available upon request)

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to ICH Q7 guidelines for active pharmaceutical ingredients, with full traceability from raw materials to final packaging. Testing includes HPLC purity assay, residual solvent analysis (GC), heavy metals (ICP-MS), and chiral purity verification (Chiral HPLC). Compliant with USP & EP monograph requirements where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store at 15–25°C in a dry, well-ventilated area. Due to its light-sensitive nature, minimize exposure to ambient and UV light during handling and dispensing. Avoid repeated opening of containers to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥99.5%
Related Substances (HPLC)	≤0.3% total impurities
Single Impurity	≤0.1%
Residual Solvents (GC)	Meets ICH Q3C limits
Water (Karl Fischer)	≤0.5%
Heavy Metals	≤10 ppm
Optical Rotation ([α]D²⁵)	–24.5° to –26.5° (c = 1 in DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.