Description

2-Chloro-5-Trifluoromethyl-Nicotinonitrile is a high-value, multi-functional heterocyclic building block used in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its unique trifluoromethyl and nitrile functionalities enable precise molecular modifications. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex nitrogen-containing scaffolds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the pyridine and trifluoromethyl groups.
• Material Science Research: Serves as a building block for creating specialized ligands, functional polymers, and organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific nitrile derivative.

Basic Information

Product Name	2-Chloro-5-Trifluoromethyl-Nicotinonitrile
CAS No.	624734-22-1
Molecular Formula	C7H2ClF3N2
Molecular Weight	206.55 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)nicotinonitrile; 2-Chloro-5-(trifluoromethyl)pyridine-3-carbonitrile; 3-Cyano-2-chloro-5-(trifluoromethyl)pyridine; 2-Chloro-5-trifluoromethyl-3-cyanopyridine; 2-Chloro-5-trifluoromethylpyridine-3-carbonitrile; 624734-22-1; CTFN
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Trifluoromethyl-Nicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect product stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.