Description

Wee1 Inhibitor CAS NO 622855-37-2 is a potent and selective small molecule inhibitor of the Wee1 kinase, a key regulator of the G2/M cell cycle checkpoint. This compound is of significant value in oncology research for its ability to induce synthetic lethality in cancer cells with specific DNA repair deficiencies, such as p53 mutations. It is primarily needed by pharmaceutical R&D teams, academic cancer research laboratories, and biotechnology companies focused on developing novel targeted cancer therapies and combination treatment strategies.

Application

• Oncology Research & Drug Discovery: A critical tool for studying cell cycle regulation, DNA damage response pathways, and mechanisms of synthetic lethality in cancer models.
• Preclinical Cancer Studies: Used in in vitro and in vivo experiments to evaluate the efficacy of Wee1 inhibition as a monotherapy or in combination with chemotherapy, radiation, or other targeted agents (e.g., PARP inhibitors).
• Biomarker Identification: Employed to identify predictive biomarkers of response to Wee1 inhibitor therapy, helping to stratify patient populations for clinical trials.
• Mechanistic Pharmacology: Serves as a reference standard in biochemical and cellular assays to characterize the potency and selectivity of novel Wee1 kinase inhibitors.
• Combination Therapy Development: Investigated for its potential to overcome tumor resistance to standard DNA-damaging therapies, informing next-generation treatment protocols.

Basic Information

Product Name	Wee1 Inhibitor
CAS No.	622855-37-2
Molecular Formula	C₁₆H₁₇N₅O₃S
Molecular Weight	359.40 g/mol
Synonyms	MK-1775; AZD-1775; 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one; Adavosertib; Wee1 Kinase Inhibitor AZD1775; Wee1 Inhibitor MK1775; 1H-Pyrazolo[3,4-d]pyrimidin-1-one, 2-allyl-1-(6-(1-hydroxy-1-methylethyl)-2-pyridinyl)-6-((4-(4-methyl-1-piperazinyl)phenyl)amino)-
EINECS	Contact for details

Quality Control

Our Wee1 Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with research-grade standards. We support our clients' regulatory needs with comprehensive documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.