Description

Tradipitant CAS NO 622370-35-8 is a high-purity, small molecule pharmaceutical intermediate and research chemical. This compound is of significant commercial interest for its role in the development of novel therapeutic agents targeting neurokinin-1 (NK1) receptors. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in advanced drug synthesis and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting the NK1 receptor pathway.
• Research & Development: Used in preclinical and clinical research for investigating treatments for conditions like nausea, vomiting, pruritus, and anxiety disorders.
• Reference Standard: Serves as an analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Employed in route scouting, optimization, and scale-up activities for efficient API manufacturing.
• Biochemical Research: A tool compound for studying NK1 receptor binding, signal transduction, and related neuropharmacology.
• Custom Synthesis: Starting material for the preparation of novel analogs and derivatives in medicinal chemistry programs.

Basic Information

Product Name	Tradipitant
CAS No.	622370-35-8
Molecular Formula	C₂₃H₂₅FN₄O₂
Molecular Weight	408.47 g/mol
Synonyms	VLY-686; Tradipitant (VLY-686); (2R,4S)-N-[(1S)-1-[4-(5-Fluoro-2-pyrimidinyl)-1-piperazinyl]carbonyl]-2-(3,5-bis(trifluoromethyl)phenyl)-2-methylpropyl]-2-[(3,5-bis(trifluoromethyl)phenyl)methoxy]-4-phenyl-3-piperidinecarboxamide; LY686017; Tradipitant [USAN]; UNII-6H8V3Z4T6R
EINECS	Contact for details

Quality Control

Our Tradipitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.