Description

4-[5-(Trifluoromethyl)Pyridin-2-Yl]Benzyl Chloride is a high-value, multi-functional chemical intermediate characterized by its reactive benzyl chloride group and trifluoromethylpyridine moiety. This compound matters for its critical role in the synthesis of advanced molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a key strategy for modulating bioactivity and metabolic stability. It is primarily needed by R&D chemists and process development scientists working on novel active ingredients, including kinase inhibitors, herbicides, and fungicides.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for functionalized ligands and monomers in the development of specialty polymers and advanced materials.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological systems and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	4-[5-(Trifluoromethyl)Pyridin-2-Yl]Benzyl Chloride
CAS No.	613239-76-2
Molecular Formula	C13H9ClF3N
Molecular Weight	271.66 g/mol
Synonyms	2-[(4-(Chloromethyl)phenyl]-5-(trifluoromethyl)pyridine; 4-(5-(Trifluoromethyl)pyridin-2-yl)benzyl chloride; 2-(4-Chloromethylphenyl)-5-trifluoromethylpyridine; 4-(5-Trifluoromethyl-2-pyridinyl)benzyl chloride; (4-(5-(Trifluoromethyl)pyridin-2-yl)phenyl)methanol chloride
EINECS	Contact for details

Quality Control

Our production of 4-[5-(Trifluoromethyl)Pyridin-2-Yl]Benzyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We operate under a quality system aligned with cGMP principles for active pharmaceutical ingredients (APIs), ensuring suitability for demanding R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.