Description

2-Cyano-5-Fluorobenzene-1-Sulfonyl Chloride is a high-purity, multi-functional chemical building block essential for advanced organic synthesis. Its molecular structure, featuring both a reactive sulfonyl chloride group and a cyano substituent on a fluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require fluorinated aromatic components.
• Material Science Research: Serves as a precursor for functional polymers and advanced materials where the introduction of sulfonyl and cyano groups modifies material properties.
• Chemical Biology & Proteomics: Acts as a reactive handle in chemical probes and activity-based protein profiling (ABPP) reagents due to its electrophilic sulfonyl chloride moiety.
• Dye & Pigment Intermediate: Employed in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.
• Cross-Coupling Reactions: A valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.

Basic Information

Product Name	2-Cyano-5-Fluorobenzene-1-Sulfonyl Chloride
CAS No.	612541-15-8
Molecular Formula	C7H3ClFNO2S
Molecular Weight	219.62 g/mol
Synonyms	5-Fluoro-2-cyanobenzenesulfonyl chloride; 2-Cyano-5-fluorobenzenesulfonyl chloride; 5-Fluoro-2-cyanobenzene-1-sulfonyl chloride; 2-Fluoro-5-cyanobenzenesulfonyl chloride; 5-Fluorophthalonitrile-6-sulfonyl chloride; 2-Fluoro-5-(chlorosulfonyl)benzonitrile; Benzonitrile, 2-fluoro-5-(chlorosulfonyl)-; 612541-15-8
EINECS	Contact for details

Quality Control

Our 2-Cyano-5-Fluorobenzene-1-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.