Description

Gsk-3 Inhibitor 1 CAS NO 603272-51-1 is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3), a key enzyme involved in numerous cellular signaling pathways. This compound is a critical research tool for studying the role of GSK-3 in diseases such as diabetes, neurodegenerative disorders, and cancer. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Biomedical Research: Used as a selective inhibitor to study the physiological and pathological roles of GSK-3 isoforms (α and β) in cellular models.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in high-throughput screening and structure-activity relationship (SAR) studies for novel therapeutics.
• Neurological Disease Research: Investigated for its potential neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and mood disorders.
• Metabolic Disorder Studies: Applied in research focused on insulin signaling, glucose metabolism, and the pathophysiology of type 2 diabetes.
• Oncology Research: Explored for its effects on cell proliferation, apoptosis, and the Wnt/β-catenin signaling pathway in various cancer cell lines.
• Stem Cell Research: Used to modulate Wnt signaling to influence stem cell differentiation and self-renewal.

Basic Information

Product Name	Gsk-3 Inhibitor 1
CAS No.	603272-51-1
Molecular Formula	C₁₆H₁₂N₄O
Molecular Weight	276.29 g/mol
Synonyms	6-Bromoindirubin-3'-oxime; BIO; (2'Z,3'E)-6-Bromoindirubin-3'-oxime; GSK-3 Inhibitor IX; GSK-3β Inhibitor IX; 6-BIO; Axon 1386; 6-Bromoindirubin-3'-oxime (BIO); 6-Br-IO
EINECS	Contact for details

Quality Control

Our Gsk-3 Inhibitor 1 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Orange to red solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.