Description

Azeliragon is a potent and selective small molecule inhibitor of the Receptor for Advanced Glycation Endproducts (RAGE). This compound is of significant interest in pharmaceutical research and development due to its targeted mechanism of action. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for investigating inflammatory pathways, neurodegenerative diseases, and diabetic complications.

Application

• Pharmaceutical Research & Development: A key tool compound for studying the role of RAGE signaling in various disease models, including Alzheimer's disease, diabetes, and cancer.
• Neuroinflammation Studies: Used in preclinical research to investigate the inhibition of neuroinflammatory processes associated with neurodegenerative disorders.
• Diabetic Complications Research: Applied in studies targeting the pathophysiology of diabetic nephropathy, retinopathy, and cardiovascular issues linked to AGE-RAGE axis activation.
• Inflammatory Pathway Analysis: Serves as a specific probe to dissect inflammatory cascades in cellular and animal models of chronic inflammation.
• Drug Discovery Programs: Employed as a reference standard or lead compound in the discovery of novel RAGE antagonists for therapeutic applications.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental biological studies on receptor-ligand interactions and signal transduction.

Basic Information

Product Name	Azeliragon
CAS No.	603148-36-3
Molecular Formula	C₂₃H₂₀F₃N₃O₃
Molecular Weight	443.42 g/mol
Synonyms	TTP488; PF-04494700; 4-Chloro-N-[(4-fluoro-3-methoxyphenyl)methyl]-3-[(3-methoxy-3-oxopropanoyl)amino]-5-(trifluoromethyl)benzamide; RAGE Inhibitor; Azeliragon (TTP488); Advanced Glycation Endproduct Receptor Inhibitor
EINECS	Contact for details

Quality Control

Our Azeliragon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.