Description

4-[3,5-Bis(Trifluoromethyl)Phenyl]Benzaldehyde is a high-value, multi-fluorinated aromatic aldehyde building block. This compound matters for its unique structural features, combining a reactive benzaldehyde group with a highly electron-deficient and lipophilic bis(trifluoromethyl)phenyl moiety, which is critical for modulating the physicochemical properties of advanced materials and active molecules. It is primarily needed by R&D and production chemists in the pharmaceutical, agrochemical, and specialty materials industries for synthesizing novel compounds with enhanced metabolic stability, bioavailability, and specific electronic characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, receptor antagonists, and other small-molecule drugs where the trifluoromethyl groups improve lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, helping to fine-tune dielectric anisotropy, viscosity, and thermal stability.
• Polymer & Resin Modifier: Incorporated into polymer backbones or as a cross-linking agent to create specialty polymers with enhanced chemical resistance, thermal properties, and low surface energy.
• Catalyst & Ligand Development: Utilized in the synthesis of novel fluorinated ligands for transition metal catalysis, enabling reactions under milder conditions or with improved selectivity.
• Organic Synthesis Building Block: The aldehyde group is a versatile handle for further transformations (e.g., condensation, reduction, oxidation) to create complex, fluorinated molecular architectures for various R&D applications.

Basic Information

Product Name	4-[3,5-Bis(Trifluoromethyl)Phenyl]Benzaldehyde
CAS No.	602307-22-2
Molecular Formula	C15H7F6O
Molecular Weight	318.21 g/mol
Synonyms	4-[3,5-Bis(trifluoromethyl)phenyl]benzaldehyde; [3,5-Bis(trifluoromethyl)phenyl]-4-formylbenzene; 4-Formyl-[1,1'-biphenyl]-3',5'-bis(trifluoromethyl); 4-(3,5-Bis(trifluoromethyl)phenyl)benzaldehyde; 4-(3,5-Di(trifluoromethyl)phenyl)benzaldehyde; 3',5'-Bis(trifluoromethyl)[1,1'-biphenyl]-4-carboxaldehyde; 4-Carboxybenzaldehyde-3',5'-bis(trifluoromethyl) derivative (aldehyde form)
EINECS	Contact for details

Quality Control

Our 4-[3,5-Bis(Trifluoromethyl)Phenyl]Benzaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive R&D and scale-up processes. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.