Description

Gsk-3Beta Inhibitor Xii is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 beta (GSK-3β), a key enzyme involved in numerous cellular signaling pathways. This compound is a critical research tool for investigating the role of GSK-3β in diseases such as neurological disorders, diabetes, and cancer. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Biomedical Research: A key reagent for studying the Wnt/β-catenin signaling pathway, insulin signaling, and cell cycle regulation in vitro.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool compound in high-throughput screening and lead optimization for neurodegenerative and metabolic diseases.
• Oncology Research: Investigated for its potential to modulate apoptosis and proliferation in various cancer cell lines.
• Neurological Disease Models: Applied in research models for Alzheimer's disease, bipolar disorder, and other conditions linked to GSK-3β dysregulation.
• Stem Cell Research: Used to manipulate signaling pathways to control stem cell differentiation and self-renewal.
• Biochemical Assay Development: Serves as a control inhibitor in kinase activity assays to validate experimental systems.

Basic Information

Product Name	Gsk-3Beta Inhibitor Xii
CAS No.	601514-19-6
Molecular Formula	C₁₆H₁₂N₄OS
Molecular Weight	308.36 g/mol
Synonyms	6-Bromoindirubin-3'-oxime; BIO; (2'Z,3'E)-6-Bromoindirubin-3'-oxime; GSK-3 Inhibitor IX; GSK-3β Inhibitor XII; 6-Bromoindirubin-3'-oxime (BIO); 6-Br-IO; Axon 1386
EINECS	Contact for details

Quality Control

Our Gsk-3Beta Inhibitor Xii is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.