Description

4-Methoxybenzoic Acid-α-13C is a stable isotope-labeled derivative of 4-methoxybenzoic acid (p-anisic acid), where the carbon atom at the alpha position relative to the carboxyl group is the carbon-13 isotope. This compound is a critical tool in advanced analytical chemistry, enabling precise quantitative analysis and metabolic pathway tracing. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical reagent industries for use as an internal standard in mass spectrometry, NMR spectroscopy, and in the development of labeled drug candidates.

Application

• Internal Standard for Quantitative Analysis: Serves as a high-purity, isotopically distinct reference compound in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) for the accurate quantification of p-anisic acid and related compounds.
• Metabolic Pathway Tracing: Used in biomedical and pharmacological research to study the absorption, distribution, metabolism, and excretion (ADME) of compounds containing the 4-methoxybenzoic acid moiety.
• NMR Spectroscopy: Provides a non-radioactive tracer for reaction mechanism studies and structural elucidation using 13C Nuclear Magnetic Resonance spectroscopy.
• Pharmaceutical Development: Employed in the synthesis of carbon-13 labeled drug candidates and metabolites for clinical research and regulatory submission packages.
• Environmental and Food Analysis: Acts as a stable isotope-labeled surrogate or standard in method development for detecting phenolic acids in complex matrices.
• Chemical Synthesis: Used as a labeled building block for the preparation of more complex 13C-labeled fine chemicals and specialty materials.

Basic Information

Product Name	4-Methoxybenzoic Acid-α-13C
CAS No.	69838-89-7
Molecular Formula	C7H8O3 (with 13C at alpha position)
Molecular Weight	~153.14 g/mol (13C adjusted)
Synonyms	p-Anisic Acid-α-13C; 4-Methoxybenzoic Acid-1-13C; 4-Methoxybenzoic-13C Acid; (13C)Carboxy-4-methoxybenzene; Benzoic acid, 4-methoxy-, (13C)carboxy-; 13C Labeled p-Anisic Acid; 4-Methoxy-1-13C-benzoic Acid; [1-13C]-4-Methoxybenzoic Acid
EINECS	Contact for details

Quality Control

Our 4-Methoxybenzoic Acid-α-13C is manufactured under strict quality control protocols to ensure exceptional isotopic and chemical purity, essential for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We support research and industrial standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to maintain isotopic integrity and prevent contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (13C labeled)
Purity (HPLC)	≥98.0%
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity (by titration)	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.