Description

Vindesine n-(3-Hydroxypropyl)Amide is a semi-synthetic derivative of the vinca alkaloid vindesine, designed to enhance solubility and modify pharmacological properties. This compound is of significant interest in pharmaceutical research and development, particularly for its potential as a cytotoxic agent. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel chemotherapeutic agents and targeted drug delivery systems.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel anti-cancer drug candidates and prodrugs.
• Biomedical Research: Used as a reference standard or active compound in in vitro and in vivo studies to investigate mechanisms of tubulin inhibition and apoptosis.
• Drug Conjugate Development: The hydroxypropyl amide moiety provides a functional handle for conjugation with antibodies, peptides, or polymers to create targeted therapies.
• Structure-Activity Relationship (SAR) Studies: Employed to understand how chemical modifications to the vindesine core affect potency, selectivity, and pharmacokinetics.
• Analytical Standard: Used in quality control laboratories for method development and validation in HPLC or LC-MS assays.

Basic Information

Product Name	Vindesine n-(3-Hydroxypropyl)Amide
CAS No.	69783-92-2
Molecular Formula	C28H41N5O6
Molecular Weight	543.66 g/mol
Synonyms	Vindesine 3'-Hydroxypropylamide; Vindesine Hydroxypropyl Amide; N-(3-Hydroxypropyl)vindesine Amide; Deacetylvinblastine 23-amide, N-(3-hydroxypropyl)-; LY 119863 (potential research code); Vindesine derivative LY-119863; 3'-Hydroxypropylamide of Vindesine
EINECS	Contact for details

Quality Control

Our Vindesine n-(3-Hydroxypropyl)Amide is produced under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.