Description

(5Z)-6A-Carbaprostaglandin I2 is a synthetic carbacyclin analog, a stable and potent prostacyclin (PGI2) mimetic. This compound is valued for its significant biological activity, particularly as a platelet aggregation inhibitor and vasodilator, offering enhanced metabolic stability compared to natural prostacyclin. It is a critical research chemical for pharmaceutical development and life science research, primarily targeting cardiovascular and pulmonary research applications. Researchers and developers in the pharmaceutical and biotechnology sectors utilize this high-purity compound for drug discovery and advanced biochemical studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel cardiovascular therapeutics.
• Platelet Aggregation Studies: Used in vitro and ex vivo to study mechanisms of thrombosis and hemostasis due to its potent anti-aggregatory properties.
• Vascular Biology Research: Employed to investigate vasodilation, pulmonary hypertension, and endothelial cell function as a stable PGI2 receptor agonist.
• Biochemical Pathway Analysis: A vital tool for probing the cyclooxygenase and prostacyclin synthase pathways in cellular signal transduction research.
• Drug Discovery Screening: Utilized in high-throughput screening assays to identify and validate new compounds targeting the IP receptor.
• Academic & Institutional Research: Supports fundamental research in pharmacology, physiology, and molecular biology within university and government laboratories.

Basic Information

Product Name	(5Z)-6A-Carbaprostaglandin I2
CAS No.	69609-77-4
Molecular Formula	C₂₁H₃₂O₄
Molecular Weight	348.48 g/mol
Synonyms	6a-Carba-PGI2; Carbacyclin; (5Z)-Carbaprostacyclin; 6a-Carbaprostaglandin I2; 9-Deoxy-9a-aza-11a-homo-13,14-dihydro-prostaglandin I2; UNII-9H19883G6F; Cicaprost impurity; Carbaprostacyclin analog
EINECS	Contact for details

Quality Control

Our (5Z)-6A-Carbaprostaglandin I2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.