Description

Isopropyl Unoprostone is a synthetic prostaglandin analog, a high-purity active pharmaceutical ingredient (API) with significant therapeutic relevance. Its primary value lies in its potent biological activity, making it a critical component for advanced ophthalmic formulations. This compound is essential for pharmaceutical manufacturers and research institutions focused on developing treatments for ocular conditions such as glaucoma and ocular hypertension. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final medicinal products.

Application

• Ophthalmic Drug Manufacturing: Primary active ingredient in prescription eye drop formulations for lowering intraocular pressure.
• Glaucoma Treatment: Key component in medications designed to manage open-angle glaucoma and ocular hypertension.
• Pharmaceutical Research & Development: Used as a reference standard and building block in R&D for novel prostaglandin-based therapies.
• API Synthesis: Serves as a crucial intermediate or final API in the synthesis of specialized ophthalmic drugs under cGMP conditions.
• Clinical Trial Materials: Supplied as a qualified material for preclinical studies and clinical trials investigating new ophthalmic treatments.

Basic Information

Product Name	Isopropyl Unoprostone
CAS No.	69553-75-9
Molecular Formula	C₂₅H₄₄O₅
Molecular Weight	424.62 g/mol
Synonyms	Unoprostone Isopropyl Ester; UF-021; Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-buten-1-yl]cyclopentyl]-5-heptenoate; 13,14-Dihydro-15-deoxy-17,18,19,20-tetranor-16-phenoxy-PGF₂α isopropyl ester; UNOP; UF 021
EINECS	Contact for details

Quality Control

Our Isopropyl Unoprostone is manufactured and tested to meet stringent pharmaceutical-grade standards. Quality is assured through a comprehensive analytical program including HPLC, NMR, and mass spectrometry for identity, purity, and impurity profile confirmation. We provide full traceability and support regulatory filings with detailed documentation. Certificates of Analysis (COA) are available upon request, and the material can be supplied to meet specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label. The material is easily oxidized and light-sensitive; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.