Description

3-Ethynyl-1,2,4,5-Tetrafluoro-Benzene is a high-value, multi-fluorinated aromatic building block featuring a reactive ethynyl group. This compound matters for its unique structural combination, enabling the synthesis of complex fluorinated molecules with tailored electronic and physical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides with enhanced efficacy and environmental profiles.
• Material Science: Serves as a monomer or cross-linker in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: Employed in palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Heck) to introduce fluorinated aryl-ethynyl motifs.
• Ligand & Catalyst Development: Useful for synthesizing novel fluorinated ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Ethynyl-1,2,4,5-Tetrafluoro-Benzene
CAS No.	69442-35-9
Molecular Formula	C8H2F4
Molecular Weight	174.10 g/mol
Synonyms	1-Ethynyl-2,3,5,6-Tetrafluorobenzene; 2,3,5,6-Tetrafluoroethynylbenzene; Tetrafluoroethynylbenzene; 3-Ethynyltetrafluorobenzene; 1,2,4,5-Tetrafluoro-3-ethynylbenzene; 3-Ethynyl-1,2,4,5-tetrafluorobenzol
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-1,2,4,5-Tetrafluoro-Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizers.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.