Description

Pemirolast is a selective mast cell stabilizer and anti-allergic agent, primarily recognized for its role in ophthalmic solutions. This compound matters for its specific pharmacological action in inhibiting the release of inflammatory mediators, which is critical for managing allergic conjunctivitis. Pharmaceutical manufacturers and research institutions developing ophthalmic formulations are the primary users of this active pharmaceutical ingredient (API). Its consistent quality and stability are paramount for ensuring the efficacy and safety of the final medicinal product.

Application

• Ophthalmic Pharmaceutical Formulations: Primary use as the active ingredient in eye drops for the treatment and prevention of allergic conjunctivitis, vernal keratoconjunctivitis, and other allergic eye conditions.
• Mast Cell Stabilization Research: A valuable reference standard and tool compound in preclinical research investigating mast cell biology, histamine release pathways, and anti-allergic mechanisms of action.
• API Intermediate Synthesis: Serves as a key intermediate in the synthesis of more complex pharmaceutical compounds targeting allergic and inflammatory pathways.
• Analytical Standard: Used in quality control laboratories as a high-purity reference standard for HPLC, LC-MS, or other analytical methods to assay drug products and raw materials.
• Veterinary Ophthalmology: Potential application in developing ophthalmic treatments for allergic eye conditions in companion animals.

Basic Information

Product Name	Pemirolast
CAS No.	69372-19-6
Molecular Formula	C10H8N6O
Molecular Weight	228.21 g/mol
Synonyms	Pemirolast Potassium; Alegysal; TBX; 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one; 4H-Pyrido[1,2-a]pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-; Pemirolast (free acid); AA-861; Pemirolast acid
EINECS	Contact for details

Quality Control

Our Pemirolast is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis to ensure it meets stringent pharmaceutical-grade specifications. We provide full traceability and support regulatory submissions with comprehensive documentation. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect contents from moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.