Description

8-Ketodeoxycoformycin is a purine nucleoside analog and a key intermediate in the synthesis of biologically active compounds. This compound matters for its role in the research and development of pharmaceutical agents, particularly those targeting adenosine deaminase and related enzymatic pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of nucleoside-based therapeutics, enzyme inhibitors, and biochemical probes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of deoxycoformycin (Pentostatin) analogs and related nucleoside drugs.
• Biochemical Research: Used as a reference standard or inhibitor in enzymatic studies, particularly those involving adenosine deaminase (ADA) and purine metabolism.
• Medicinal Chemistry: Serves as a scaffold for the design and development of novel chemotherapeutic agents and immunosuppressants.
• Academic Research: Employed in universities and research institutes for investigating nucleoside chemistry, enzyme kinetics, and metabolic pathways.
• Process Development: Utilized in the scale-up and optimization of synthetic routes for complex nucleoside active pharmaceutical ingredients (APIs).

Basic Information

Product Name	8-Ketodeoxycoformycin
CAS No.	69196-03-8
Molecular Formula	C11H15N5O4
Molecular Weight	281.27 g/mol
Synonyms	8-Oxodeoxycoformycin; 8-Oxo-2'-deoxycoformycin; (2R,3S,4R,5R)-2-(6-Amino-8-oxo-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; 8-Keto-dCF; 8-Oxo-dCF; 8-Oxo-2'-deoxycoformycin; 8-Keto-2'-deoxycoformycin
EINECS	Contact for details

Quality Control

Our 8-Ketodeoxycoformycin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). Certificates of Analysis (COA) detailing batch-specific results are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.