Description

Trifluoromethoxyacetic Acid is a versatile fluorinated organic acid building block, essential for introducing the trifluoromethoxy group into complex molecular architectures. Its unique structure combines the electron-withdrawing properties of fluorine with the reactivity of a carboxylic acid, making it a critical intermediate for advanced synthesis. This compound is primarily sought by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for developing novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethoxy group improves compound efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric anisotropy and stability.
• Polymer & Material Science: Employed to modify polymer side chains, imparting desirable properties such as chemical resistance, low surface energy, and thermal stability to specialty coatings and resins.
• Organic Synthesis Reagent: Acts as a versatile reagent for peptide coupling, esterification, and amidation reactions in complex organic molecule construction.

Basic Information

Product Name	Trifluoromethoxyacetic Acid
CAS No.	69105-00-6
Molecular Formula	C3H3F3O3
Molecular Weight	144.05 g/mol
Synonyms	2,2,2-Trifluoro-1-methoxyacetic Acid; Acetic Acid, 2,2,2-Trifluoro-1-methoxy-; Trifluoromethyl Ether Acetic Acid; α-Methoxy-α,α,α-trifluoroacetic Acid; TFMOAA; CF3OCH2COOH; (Trifluoromethoxy)ethanoic Acid
EINECS	Contact for details

Quality Control

Our Trifluoromethoxyacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical and pharmaceutical-grade intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Due to its nature as a strong acid/organic solvent, handle with appropriate personal protective equipment and ensure containers are kept tightly sealed when not in use to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.