Description

2-Dimethylaminonaphthalene-5-Sulfonyl Chloride is a specialized sulfonyl chloride derivative, primarily recognized as a key intermediate for the synthesis of dansyl chloride, a vital fluorescent labeling reagent. This compound is essential for researchers and manufacturers requiring high-purity precursors for analytical and synthetic chemistry applications. It is particularly valuable in the pharmaceutical, biotechnology, and life science research sectors for the derivatization and detection of amines, amino acids, and peptides.

Application

• Fluorescent Probe Synthesis: Primary precursor for the production of dansyl chloride, a widely used fluorescent tag.
• Analytical Chemistry: Derivatization agent for the HPLC and LC-MS analysis of amines, amino acids, peptides, and pharmaceuticals to enhance detection sensitivity.
• Bioconjugation: Used in the labeling of proteins, antibodies, and other biomolecules for fluorescence microscopy, flow cytometry, and immunoassays.
• Organic Synthesis: Versatile building block for introducing the dansyl fluorophore into more complex molecules for material science and chemical biology research.
• Biochemical Research: Tool compound for studying enzyme activity, protein-protein interactions, and cellular processes via fluorescence.
• Dye and Pigment Intermediates: Serves as an intermediate in the synthesis of certain specialized dyes and fluorescent materials.

Basic Information

Product Name	2-Dimethylaminonaphthalene-5-Sulfonyl Chloride
CAS No.	69037-87-2
Molecular Formula	C₁₂H₁₂ClNO₂S
Molecular Weight	269.75 g/mol
Synonyms	5-(Dimethylamino)naphthalene-1-sulfonyl chloride; Dansyl chloride precursor; 1-Dimethylaminonaphthalene-5-sulfonyl chloride; DNSC; DANSYL-Cl intermediate; 5-Dimethylamino-1-naphthalenesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Dimethylaminonaphthalene-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic and light-sensitive nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.