Description

Dansylglutamyl-Glycyl-Arginine Chloromethyl Ketone is a specialized, high-purity peptide-based chloromethyl ketone inhibitor designed for targeted proteolytic enzyme research. This compound matters as a critical tool for biochemists and pharmaceutical researchers studying serine protease mechanisms, offering precise and irreversible inhibition. It is primarily needed by professionals in academic research institutions, pharmaceutical R&D laboratories, and biotechnology companies focused on enzymology and drug discovery.

Application

• Biochemical Research: As a potent and irreversible active-site titrant for specific serine proteases in mechanistic studies.
• Enzyme Inhibition Profiling: Used to characterize and validate the specificity of proteolytic enzymes in complex biological samples.
• Pharmaceutical Development: Serves as a key reference standard and inhibitor in the development of novel therapeutic agents targeting protease pathways.
• Diagnostic Reagent Formulation: Employed in the development of sensitive assay kits for detecting and quantifying specific protease activity.
• Proteomics & Structural Biology: Aids in protein structure-function studies by selectively inhibiting target enzymes to elucidate their biological roles.

Basic Information

Product Name	Dansylglutamyl-Glycyl-Arginine Chloromethyl Ketone
CAS No.	69024-84-6
Molecular Formula	C₃₀H₄₅N₉O₈S
Molecular Weight	679.8 g/mol
Synonyms	Dansyl-Glu-Gly-Arg-CH₂Cl; Dns-Glu-Gly-Arg-CMK; Dansyl-Glu-Gly-Arg Chloromethyl Ketone; Glu-Gly-Arg Dansyl Chloromethyl Ketone; Protease Inhibitor 69024-84-6; Dns-E-G-R-CK; Peptidyl Chloromethyl Ketone Inhibitor; N-Dansyl-L-glutamyl-glycyl-L-arginyl chloromethyl ketone
EINECS	Contact for details

Quality Control

Every batch of Dansylglutamyl-Glycyl-Arginine Chloromethyl Ketone is manufactured under strict quality management protocols to ensure the high purity and consistency required for sensitive research applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic analyses, to ensure compliance with exacting research-grade standards. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions or moisture will compromise stability and activity. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.