Description

(+)-Nicotine (+)-Di-p-Toluoyltartrate Salt is a high-purity, enantiomerically pure salt derivative of nicotine, specifically designed for advanced research and development applications. This compound is critical for studies requiring the precise biological activity profile of the (+)-nicotine enantiomer, free from the confounding effects of its (-)-counterpart. It serves as an essential chiral intermediate and reference standard for pharmaceutical researchers, analytical chemists, and toxicologists working in neuroscience, addiction research, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the calibration and validation of analytical methods (HPLC, GC-MS) to quantify nicotine enantiomers in complex matrices.
• Neuroscience Research: A key tool for investigating the specific pharmacological effects, receptor binding affinity, and metabolic pathways of the (+)-nicotine enantiomer in central nervous system studies.
• Chiral Synthesis Intermediate: Employed in the asymmetric synthesis of novel nicotinic analogs and other chiral molecules for drug discovery programs.
• Toxicological Studies: Utilized in controlled experiments to understand the enantioselective toxicity, pharmacokinetics, and metabolic fate of nicotine derivatives.
• Quality Control Laboratories: Serves as a critical purity and identity reference material for manufacturers of nicotine and related alkaloid products.

Basic Information

Product Name	(+)-Nicotine (+)-Di-p-Toluoyltartrate Salt
CAS No.	68935-27-3
Molecular Formula	C30H32N2O8
Molecular Weight	548.59 g/mol
Synonyms	(+)-Nicotine Di-p-toluoyltartrate; (S)-Nicotine (2R,3R)-Di-p-toluoyltartrate Salt; Nicotine Ditoluoyltartrate; (S)-3-(1-Methyl-2-pyrrolidinyl)pyridine (2R,3R)-Bis(4-methylbenzoyl)tartrate; L-Nicotine D-(-)-Di-p-Toluoyltartrate; Nicotine Hydrogen Ditoluoyltartrate; (S)-Nicotine (R,R)-O,O'-Di-p-toluoyltartrate
EINECS	Contact for details

Quality Control

Every batch of (+)-Nicotine (+)-Di-p-Toluoyltartrate Salt is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and reliability for your critical research. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as enantiomeric excess, assay, and impurity profiles determined by validated methods including chiral HPLC.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Return the container to storage immediately after use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (chiral HPLC)	≥99.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.