Description

(5Z,9E,11R,12S,14Z)-8,11,12-Trihydroxyicosa-5,9,14-Trienoic Acid is a specialized eicosanoid derivative, a key intermediate in the biosynthesis of bioactive lipid mediators. This compound matters for its role as a precursor in the lipoxygenase pathway, leading to the formation of important signaling molecules involved in physiological and inflammatory responses. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors for drug discovery, biochemical research, and the synthesis of reference standards.

Application

• Biochemical Research: Used as a critical intermediate and reference standard in studies of eicosanoid biosynthesis, lipid metabolism, and inflammatory pathways.
• Pharmaceutical Development: Serves as a key starting material or precursor in the synthesis of novel anti-inflammatory agents and lipid-based therapeutics.
• Enzymology Studies: Employed as a substrate for lipoxygenase and other enzymes to investigate reaction mechanisms and enzyme kinetics.
• Cell Signaling Research: Utilized in cellular assays to study the downstream effects of specific hydroxy fatty acid metabolites on cell function.
• Analytical Standard: Acts as a high-purity calibration standard for analytical methods like HPLC and LC-MS in lipidomics and metabolomics.

Basic Information

Product Name	(5Z,9E,11R,12S,14Z)-8,11,12-Trihydroxyicosa-5,9,14-Trienoic Acid
CAS No.	68860-46-8
Molecular Formula	C₂₀H₃₄O₅
Molecular Weight	354.48 g/mol
Synonyms	8,11,12-Trihydroxy-5,9,14-eicosatrienoic Acid; 8,11,12-TriHETE; (5Z,9E,11R,12S,14Z)-8,11,12-Trihydroxyeicosa-5,9,14-trienoic Acid; 8(R),11(R),12(S)-Trihydroxy-5(Z),9(E),14(Z)-eicosatrienoic Acid; 8,11,12-Trihydroxyicosa-5,9,14-trienoic Acid; 8,11,12-THETA; 8,11,12-TriHETrE
EINECS	Contact for details

Quality Control

Our (5Z,9E,11R,12S,14Z)-8,11,12-Trihydroxyicosa-5,9,14-Trienoic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.