Description

Prost-13-Ene-1,20-Dioic Acid, 15-Hydroxy-16,16-Dimethyl-9-(Tetrahydro-2H-Pyran-2-Yl)Oxy-, 1-Methyl 20-(1-Methylethyl) Ester, (13E)-(+-)- is a sophisticated prostaglandin derivative and a key synthetic intermediate in advanced pharmaceutical manufacturing. This compound matters for its role in the synthesis of complex therapeutic agents, particularly in the development of prostaglandin-based drugs targeting a range of physiological pathways. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of ophthalmic solutions, cardiovascular treatments, and other specialized therapeutics. Our supply ensures the high purity and structural integrity required for critical synthetic steps.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of prostaglandin analogs and related bioactive molecules.
• Ophthalmic Drug Development: Used in research and production of prostaglandin-based medications for treating glaucoma and ocular hypertension.
• Cardiovascular Research: Serves as a precursor in studies exploring the role of prostaglandins in vascular tone and platelet aggregation.
• Chemical Synthesis: Employed in advanced organic synthesis for introducing the complex prostaglandin skeleton into target molecules.
• Biochemical Research: Used as a standard or reagent in studies investigating eicosanoid signaling pathways and receptor interactions.
• Process Development: Supports scale-up and optimization of synthetic routes for prostaglandin-derived active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	Prost-13-Ene-1,20-Dioic Acid, 15-Hydroxy-16,16-Dimethyl-9-(Tetrahydro-2H-Pyran-2-Yl)Oxy-, 1-Methyl 20-(1-Methylethyl) Ester, (13E)-(+-)-
CAS No.	68624-50-0
Molecular Formula	C25H40O7
Molecular Weight	452.59 g/mol
Synonyms	15-Hydroxy-16,16-dimethyl-9-(tetrahydro-2H-pyran-2-yl)oxy-prost-13-ene-1,20-dioic acid 1-methyl 20-(1-methylethyl) ester; (13E)-15-Hydroxy-16,16-dimethyl-9-[(tetrahydro-2H-pyran-2-yl)oxy]prosta-13-en-1,20-dioic acid 1-methyl 20-(1-methylethyl) ester; Prostaglandin F2α THP ether isopropyl ester methyl ester; PGF2α derivative THP ether; 9-THP-oxy-15-hydroxy-16,16-dimethyl-prost-13-en-1,20-dioic acid 1-methyl 20-isopropyl ester; Latanoprost intermediate; Isopropyl (1R,2R,3R,5S)-3-[(1E,3R)-4-(2,2-Dimethyl-3-hydroxy-5-oxocyclopentyl)but-1-en-1-yl]-5-[(tetrahydro-2H-pyran-2-yl)oxy]-2-[(3S)-3-hydroxy-3-methylpent-4-en-1-yl]cyclopentane-1-carboxylate (related structure).
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and structural fidelity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality system is designed to meet the exacting standards of pharmaceutical R&D and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from heat sources and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.