Description

Nap-Ouabain is a specialized cardiac glycoside derivative, structurally related to ouabain, known for its potent and specific inhibition of the Na+/K+-ATPase pump. This high-purity compound is critical for advanced biochemical and pharmacological research, particularly in studies of ion transport mechanisms, cellular signaling, and cardiovascular physiology. It serves as an essential tool for researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on cardiac function and drug discovery.

Application

• Biochemical Research: Used as a specific inhibitor of the Na+/K+-ATPase enzyme in mechanistic studies of ion transport and cellular homeostasis.
• Pharmacological Studies: Employed in cardiovascular research to investigate inotropic effects, signal transduction pathways, and the role of endogenous cardiotonic steroids.
• Cell Biology: Applied in cell culture experiments to modulate intracellular sodium and calcium concentrations, affecting various cellular processes.
• Drug Discovery & Development: Serves as a reference standard and a key pharmacological tool in screening assays and the development of novel therapeutic agents targeting heart failure.
• Academic Research: Utilized in university and institutional labs for teaching and fundamental research in physiology and molecular pharmacology.
• Diagnostic Reagent Manufacturing: May be incorporated into the production of specialized kits for research and diagnostic purposes.

Basic Information

Product Name	Nap-Ouabain
CAS No.	68613-44-5
Molecular Formula	C29H44O12
Molecular Weight	584.66 g/mol
Synonyms	Naphthyl Ouabain; 1-Naphthyl Ouabain; Ouabain 1-Naphthyl Derivative; Strophanthin G 1-Naphthyl Ester; NSC 113871; 3-[(6-Deoxy-α-L-mannopyranosyl)oxy]-1,5,11,14,19-pentahydroxy-12-[(1-hydroxy-2-naphthyl)carbonyl]oxy]card-20(22)-enolide
EINECS	Contact for details

Quality Control

Our Nap-Ouabain CAS NO 68613-44-5 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Biological Activity	Confirmed by Na+/K+-ATPase inhibition assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.