Description

p-(1,1,2,2-Tetrafluoroethoxy)Benzenesulphonyl Chloride is a high-value, fluorinated aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in introducing the unique p-(1,1,2,2-tetrafluoroethoxy)phenylsulfonyl moiety, which imparts enhanced metabolic stability, lipophilicity, and electronic properties to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients, intermediates for drug discovery, and specialized materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based active pharmaceutical ingredients (APIs), especially those requiring fluorinated side chains for improved bioavailability and patent life.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides where the fluorinated ether group enhances environmental stability and target specificity.
• Material Science: Building block for advanced polymers and liquid crystals, where the sulfonyl chloride group enables polymerization and the fluorinated segment modifies surface properties and chemical resistance.
• Chemical Biology Probes: Employed in the development of activity-based probes and covalent inhibitors for studying enzyme function and drug-target interactions.
• Custom Synthesis & Contract Research: A vital reagent for custom synthesis organizations (CSOs) and R&D labs focusing on fluorinated compound libraries and specialty chemicals.

Basic Information

Item	Details
Product Name	p-(1,1,2,2-Tetrafluoroethoxy)Benzenesulphonyl Chloride
CAS No.	68516-54-1
Molecular Formula	C8H5ClF4O3S
Molecular Weight	292.63 g/mol
Synonyms	4-(1,1,2,2-Tetrafluoroethoxy)benzenesulfonyl chloride; 1-(1,1,2,2-Tetrafluoroethoxy)-4-(chlorosulfonyl)benzene; p-(Perfluoroethoxy)benzenesulfonyl chloride; 4-(Perfluoroethoxy)phenylsulfonyl chloride; Benzenesulfonyl chloride, 4-(1,1,2,2-tetrafluoroethoxy)-; CAS 68516-54-1
EINECS	Contact for details

Quality Control

Every batch of p-(1,1,2,2-Tetrafluoroethoxy)Benzenesulphonyl Chloride is manufactured and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.