Description

11-Hydroxycamptothecin is a potent, naturally derived alkaloid and a key pharmaceutical intermediate. This compound is highly valued for its role as a precursor in the synthesis of more complex, clinically significant camptothecin analogs. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel anticancer therapeutics. Its specific hydroxylation pattern is critical for modulating biological activity and improving drug efficacy profiles.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of advanced camptothecin-derived anticancer agents, such as topotecan and irinotecan analogs.
• Oncology Research: Used as a reference standard and active compound in biochemical and pharmacological studies targeting topoisomerase I inhibition.
• Drug Discovery & Development: Employed in high-throughput screening and structure-activity relationship (SAR) studies to develop new chemotherapeutic candidates.
• Academic Research: Utilized in university and institutional labs for investigating the mechanisms of cell cycle arrest and apoptosis in cancer cell lines.
• Bioconjugation Studies: Acts as a payload for the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Analytical Standard: Provides a high-purity benchmark for quality control and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	11-Hydroxycamptothecin
CAS No.	68426-53-9
Molecular Formula	C20H16N2O5
Molecular Weight	364.35 g/mol
Synonyms	11-HCPT; (S)-11-Hydroxycamptothecin; 11-Hydroxy-20(S)-camptothecin; 20(S)-11-Hydroxycamptothecin; Camptothecin, 11-hydroxy-; 11-Hydroxy-(20S)-camptothecin; 11-Hydroxycamptothecine
EINECS	Contact for details

Quality Control

Our 11-Hydroxycamptothecin is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and pharmaceutical development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.