Description

(+)-3-(11-Ethoxy-5,10,11,11A-Tetrahydro-9-Hydroxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-2-Yl)-n-Methylpropenamide is a high-purity, chiral pyrrolobenzodiazepine derivative of significant interest in advanced pharmaceutical research. This compound serves as a critical pharmacological reference standard and a key synthetic intermediate for developing novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in medicinal chemistry and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex, biologically active molecules, particularly for oncology drug discovery programs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing and research.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore and optimize the biological activity of pyrrolobenzodiazepine-based compounds.
• Biochemical Assays: Serves as a ligand or inhibitor in enzymatic and receptor-binding assays to study specific biological pathways.
• Academic Research: Utilized in university and institutional labs for fundamental research on DNA-interactive agents and anticancer mechanisms.
• Pre-clinical Development: Acts as a candidate molecule or a direct comparator in pre-clinical pharmacological and toxicological evaluations.

Basic Information

Product Name	(+)-3-(11-Ethoxy-5,10,11,11A-Tetrahydro-9-Hydroxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-2-Yl)-n-Methylpropenamide
CAS No.	68373-94-4
Molecular Formula	C20H25N3O5
Molecular Weight	387.43 g/mol
Synonyms	DC-81; SJG-136 (Enantiomer); (+)-Pyrrolobenzodiazepine DC-81; (11S)-11-Ethoxy-8-methyl-5-oxo-2-[(1E)-3-(methylamino)-3-oxo-1-propen-1-yl]-5,10,11,11a-tetrahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepin-9-ol; PBD DC-81; NSC 684492; (11aS)-9-Hydroxy-8-methyl-11-ethoxy-5-oxo-2-[(1E)-3-(methylamino)-3-oxoprop-1-en-1-yl]-5,10,11,11a-tetrahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepine
EINECS	Contact for details

Quality Control

Our (+)-3-(11-Ethoxy-5,10,11,11A-Tetrahydro-9-Hydroxy-8-Methyl-5-Oxo-1H-Pyrrolo[2,1-C][1,4]Benzodiazepine-2-Yl)-n-Methylpropenamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity, NMR, and MS for structural confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.