Description

Digitoxin-16'-Glucuronide is a key glucuronide metabolite of the cardiac glycoside digitoxin. This compound is of significant interest for pharmaceutical research and development, particularly in the study of drug metabolism and pharmacokinetics. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical and analytical chemistry sectors, enabling precise quantification and metabolic pathway analysis.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantification of digitoxin and its metabolites in biological matrices via HPLC, LC-MS, or ELISA.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of digitoxin in preclinical and clinical research.
• Analytical Method Development: Serves as a critical component in developing and validating sensitive and specific analytical methods for therapeutic drug monitoring (TDM).
• Biochemical Research: Employed in studies focusing on the interaction of cardiac glycosides with biological systems and their glucuronidation mechanisms.
• Impurity Profiling: Used to identify and quantify related substances in the quality control of digitoxin active pharmaceutical ingredient (API) manufacturing.

Basic Information

Product Name	Digitoxin-16'-Glucuronide
CAS No.	68325-34-8
Molecular Formula	C₄₁H₆₂O₁₄
Molecular Weight	778.92 g/mol
Synonyms	Digitoxin 16'-Glucuronide; 16'-O-(β-D-Glucopyranuronosyl)digitoxin; Digitoxin 16'-β-D-Glucuronide; Digitoxin-16'-O-β-D-glucuronide; 3β-[(O-2,6-Dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-14-hydroxy-5β-card-20(22)-enolide 16'-β-D-glucopyranosiduronic acid
EINECS	Contact for details

Quality Control

Our Digitoxin-16'-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and reference standard use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.