Description

2-Chloro-6-Fluorobenzyl Bromide is a versatile and high-purity halogenated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive benzylic bromide site adjacent to chloro and fluoro substituents, enabling precise molecular construction for complex target molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, as well as in material science for creating specialized polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in constructing advanced herbicides, fungicides, and insecticides, where the halogen pattern contributes to biological activity and environmental stability.
• Liquid Crystal & OLED Material Production: Serves as a building block for fluorinated and chlorinated aromatic cores in electronic display and lighting materials.
• Cross-Coupling Reactions: An effective substrate for palladium-catalyzed reactions like Suzuki, Negishi, and Kumada couplings to form biaryl structures.
• Nucleophilic Substitution Reactions: The reactive benzyl bromide moiety allows for functionalization with various nucleophiles (amines, thiols, alkoxides) to create diverse chemical libraries.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry teams exploring new synthetic routes and optimizing scale-up processes.

Basic Information

Product Name	2-Chloro-6-Fluorobenzyl Bromide
CAS No.	68220-26-8
Molecular Formula	C7H5BrClF
Molecular Weight	223.47 g/mol
Synonyms	1-(Bromomethyl)-2-chloro-6-fluorobenzene; (2-Chloro-6-fluorophenyl)methyl bromide; α-Bromo-2-chloro-6-fluorotoluene; 2-Chloro-6-fluoro-benzylbromide; 2-Chloro-6-fluorobenzyl bromide; 2-Chloro-6-fluoro-1-(bromomethyl)benzene; o-Chloro-o-fluorobenzyl bromide
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-Fluorobenzyl Bromide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for each lot and provided with shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.