Description

4'-Deoxy Vincristine is a semi-synthetic derivative of the potent antineoplastic agent vincristine, characterized by the removal of the hydroxyl group at the 4' position of the vindoline moiety. This structural modification is of significant interest in pharmaceutical research for exploring structure-activity relationships and developing novel therapeutic agents with potentially altered pharmacokinetic or toxicity profiles. It serves as a critical reference standard and key intermediate for researchers and developers in the fields of oncology drug discovery, medicinal chemistry, and analytical method development.

Application

• Pharmaceutical Reference Standard: Used for qualitative and quantitative analysis in HPLC, LC-MS, and NMR to ensure the identity, purity, and potency of related compounds in research and quality control laboratories.
• Medicinal Chemistry Research: Serves as a crucial intermediate or precursor for the synthesis of novel vinca alkaloid analogs to study their biological activity and therapeutic potential.
• Oncology Drug Discovery: Employed in preclinical studies to investigate the impact of structural modifications on cytotoxicity, mechanism of action, and resistance profiles against various cancer cell lines.
• Biochemical Research: Utilized as a tool compound to study tubulin binding dynamics, mitotic spindle inhibition, and apoptosis pathways in cellular models.
• Analytical Method Development: Acts as a known impurity or degradation product marker during the stability testing and method validation for vincristine and related pharmaceutical formulations.

Basic Information

Item	Detail
Product Name	4'-Deoxy Vincristine
CAS No.	68135-16-0
Molecular Formula	C46H56N4O9
Molecular Weight	808.97 g/mol
Synonyms	4'-Deoxyvincristine; Deoxyvincristine; 22-Oxovincaleukoblastine, 4'-deoxy-; Leurocristine, 4'-deoxy-; Vincristine, 4'-deoxy-; 4'-Deoxy-leurocristine; (3aR,4R,5S,5aR,10bR,13aR)-4-(Acetyloxy)-3a-ethyl-9-((5S,7S,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-2,4,5,6,7,8,9,10-octahydro-1H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl)-6-formyl-5-hydroxy-8-methoxy-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 4'-Deoxy Vincristine is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided, documenting critical parameters such as assay purity and impurity profiles. We are committed to supplying materials that support reproducible and reliable scientific outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or Certificate of Analysis. For long-term storage, consider storing desiccated at -20°C. Handle the product with care to avoid contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Single Unknown Impurity (HPLC)	≤ 2.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.